US–Iran Talks in Islamabad Focus on Nuclear Deal, Sanctions, and Regional Disputes

Islamabad, US–Iran Talks, International Atomic Energy Agency, Strait of Hormuz, Washington and Tehran

Islamabad: As United States and Iranian delegations sit across the table in Islamabad for crucial negotiations, discussions are expected to be dominated by a wide but highly complex set of issues that continue to define tensions between the two sides.

The talks, hosted by Pakistan, are aimed at advancing progress on a fragile ceasefire while exploring pathways toward a broader and more durable agreement between Washington and Tehran.

According to diplomatic sources, the negotiations are structured around competing proposals. Iran has presented a 10-point framework outlining its demands, while the United States has responded with a 15-point plan of its own. Although both sides have agreed to engage in dialogue, significant differences remain at the core of the discussions.

At the center of the negotiations is Iran’s nuclear program. Washington is seeking firm guarantees that Tehran will not develop nuclear weapons, along with strict limits on uranium enrichment and enhanced monitoring by the International Atomic Energy Agency.

Iran, however, insists on its right to pursue peaceful nuclear activities, including uranium enrichment, describing it as an issue of national sovereignty.

Sanctions remain another major sticking point. Tehran is demanding the immediate and complete lifting of US and international sanctions, along with the return of frozen assets held abroad. The US position, however, favors a phased easing of restrictions linked to verifiable compliance by Iran on nuclear and security commitments.

Control and access to the strategically vital Strait of Hormuz also remain a key dispute. Iran seeks formal recognition of its regulatory role over the waterway, citing its geographic and economic significance, while the United States insists on ensuring free and secure international navigation given its importance to global energy supply.

Regional influence is another sensitive dimension of the talks. Washington is pressing for an end to Iranian support for armed groups across the Middle East, while Iran is calling for an end to military actions against those groups and broader de-escalation across regional conflicts.

Iran has also demanded the withdrawal of US forces from the region and formal guarantees of non-aggression. The United States, citing security commitments to its allies, has shown no willingness to reduce its military presence.

Another contentious issue is Iran’s ballistic missile program. The US is seeking limitations on missile development and broader defense capabilities, while Iran views such demands as restrictions on its right to self-defense.

Tehran has also raised the issue of compensation for damages resulting from recent conflict, while Washington is expected to push for accountability over attacks on US interests and allied targets.

With the two-week ceasefire period nearing its end, sources acknowledge that any progress is likely to be incremental, beginning with confidence-building measures from both sides. While no major breakthrough is expected immediately, discussions are likely to continue, raising the possibility of an extension of the ceasefire as negotiations proceed.

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